한빛사논문
- 조회1,006
Lili Wanga,b,d, Joshua A. Jackmana,b, Wei Beng Nga,b, and Nam-Joon Choa,b,c,*
aSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798
bCentre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553
cSchool of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459
dState Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, P.R. China
*To whom correspondence should be addressed.
Abstract
Wearable biosensors hold significant potential for healthcare and environmental applications, and the development of flexible and biocompatible sensing platforms for high accuracy detection of physiological biomarkers remains an elusive goal. Herein, an ultrasensitive, flexible sensor is described that is based on a 3D hierarchical biocomposite comprised of hollow, natural pollen microcapsules that are coated with a conductive graphene layer. Modular assembly of the graphene-coated microcapsules onto an ultrathin polyethylene terephthalate layer enables a highly flexible sensor configuration with tunable selectivity afforded by subsequent covalent immobilization of antibodies against target antigens. In a proof-of-concept example, the biosensor demonstrates ultrahigh sensitivity detection of prostate specific antigen (PSA) down to 1.7 × 10-15m with real-time feedback and superior performance over conventional 2D graphene-coated sensors. Importantly, the device performance is consistently high across various bending conditions. Taken together, the results demonstrated in this work highlight the merits of employing lightweight biocomposites as modular building blocks for the design of flexible biosensors with highly responsive and sensitive molecular detection capabilities.
논문정보
- Research article
- 2016년 12월 (BRIC 등록일 2018-12-04)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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