한빛사논문
- 조회2,577
Hae Woong Choi1,*, Jutamas Suwanpradid2, Il Hwan Kim3, Herman F. Staats1,4,5, Muzlifah Haniffa6,7, Amanda S. MacLeod2,4, Soman N. Abraham1,4,8,9
1Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
2Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.
3Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
4Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
5Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
6Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
7Department of Dermatology, Newcastle upon Tyne NHS Trust, Newcastle upon Tyne NE1 4LP, UK.
8Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
9Program in Emerging Infectious Diseases, Duke?National University of Singapore, Singapore 169857, Singapore.
*Corresponding author : Hae Woong Choi
Abstract
Anaphylaxis is a life-threatening allergic reaction triggered after antigen-specific immunoglobulin E (IgE) antibodies bind to target allergens. These antibodies then cross-link IgE-specific Fc receptors on the surface of mast cells. The mast cells rapidly release inflammatory mediators, including histamine, resulting in smooth muscle contraction, vasodilation, and blood vessel leakage. Because mast cells are usually found in the perivascular abluminal surface of blood vessels, it has been unclear how blood-borne allergens can interact with them. Choi et al. used live intravital imaging of the mouse vasculature to show that a specialized subset of dendritic cells sample blood-borne antigens and relay them to mast cells on the surface of microvesicles (see the Perspective by Levi-Schaffer and Scheffel). IgE-bound mast cells then vigorously degranulate after contact with these microvesicles.
논문정보
- Research article
- 2018년 11월 (BRIC 등록일 2018-11-20)
- 국외 연구진
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