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- 조회638
장자영Ja-Young Jang
세계김치연구소
Mol. Nutr. Food Res., First published: 26 October 2018 | https://doi.org/10.1002/mnfr.201800329
Mixture of Two Lactobacillus plantarum Strains Modulates the Gut Microbiota Structure and Regulatory T Cell Response in Diet‐Induced Obese Mice
Abstract
Jieun Lee1*, Ja-Young Jang1*, Min-Sung Kwon1, Seul Ki Lim1, Namhee Kim1,Jihyun Lee1, Hyo Kyeong Park1, Misun Yun1, Mi-Young Shin1,2, Hee Eun Jo1,2, Young Joon Oh1, Byung HeeRyu3, Mi YeonKo3, Wooha Joo 3 and Hak-Jong Choi1
1Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju 61755, Republic of Korea
1Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju 61755, Republic of Korea
2Divisionof Animal Science, ChonnamNational University, Gwangju 61186, Republic of Korea
3Fresh Food Research Division, Food BU, Daesang CorporationResearch Institute, lcheon 17384, Republic of Korea
*J.L. and J.Y.J. contributed equally to this work
Correspondence: Hak-Jong Choi
Abstract
Scope
*J.L. and J.Y.J. contributed equally to this work
Correspondence: Hak-Jong Choi
Abstract
Scope
The gut microbiota has been linked to diet-induced obesity, and microorganisms that influence obesity have important health implications. In this study, the anti-obesity effects of two Lactobacillus plantarum strains (DSR M2 and DSR 920) isolated from kimchi were investigated.
Methods and results
Methods and results
Mice were fed a normal or high-fat diet with or without DSR M2 and DSR 920 (DSR, 1 × 109 CFU/day) for 12 weeks. DSR improved the obesity state, as evidenced by the (i) suppressed obesity-related markers, e.g., gains in body weight and fat mass, (ii) reduced serum and liver triglyceride levels, (iii) up-regulated β-oxidation and down-regulated lipogenesis-related genes in the liver, (iv) reduced serum leptin levels, (v) altered microbial communities, (vi) increased regulatory T cell immunity, and (vii) suppressed inflammatory response. In addition, correlation analysis showed that Akkermansia muciniphila and the genus Anaerostipes which were increased in the DSR group were negatively correlated with obesity-related markers, but Mucispirillum schaedleri which was increased in the HFD group was positively correlated with serum leptin level.
Conclusion
Conclusion
Lactobacillus plantarum DSR M2 and DSR 920 are candidate probiotics for the prevention and amelioration of obesity.
Keywords : gut microbiota, inflammation,Lactobacillus plantarum, obesity, regulatory T cell
Keywords : gut microbiota, inflammation,Lactobacillus plantarum, obesity, regulatory T cell
논문정보
- Research article
- 2018년 10월 (BRIC 등록일 2018-12-07)
- 국내 연구진
- 구・농수식품
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