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Adv. Funct. Mater., First published: 25 September 2018 | https://doi.org/10.1002/adfm.201803051
Supramolecular Carbon Monoxide‐Releasing Peptide Hydrogel Patch
Inhye Kima,b, Eun Hee Hanc,d, Woo-Young Bangb, Jooyeon Ryub, Jin-Young Minb,c, Hyeong Chan Name, Won Ho Parke, Young-Ho Chungc, and Eunji Leea,*
aSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea
bGraduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea
cDivision of Bioconvergence Analysis, Korea Basic Science Institute, Cheongju 28119, Republic of Korea
dImmunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
eDepartment of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon 34134, Republic of Korea
*To whom correspondence may be addressed.
aSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea
bGraduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea
cDivision of Bioconvergence Analysis, Korea Basic Science Institute, Cheongju 28119, Republic of Korea
dImmunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
eDepartment of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon 34134, Republic of Korea
*To whom correspondence may be addressed.
Abstract
Carbon monoxide (CO) is recently accepted as a therapeutic molecule that exhibits remarkable biological actions, including anti-inflammation, antiapoptosis, and cytoprotection, at a physiological level. For clinical use without the side effect of tissue hypoxia, which arises from the uncontrolled administration of CO in the human body, CO-releasing molecules (CORMs) are developed to ensure safe and efficient CO-delivery. Herein, a syringe-injectable CO-releasing peptide hydrogel (COH) and a corresponding bioadhesive hydrogel patch (COHP), developed by rational supramolecular chemistry, to enhance the therapeutic efficacy of CO with controllable CO-release to a specific tissue is report. The injectable COH is prepared by self-assembly of the CORM-attached peptides with a gel-forming diphenylalanine-derivative, resulting in fibrillar networks and exhibiting prolonged CO-release compared with CORMs. Furthermore, Ca2+-chelating and mussel-derived catechol-functionalized peptides are introduced to afford a mechanically rigid, bioadhesive COHP that elicits cytoprotective and anti-inflammatory activities. The supramolecular COHP can be utilized in the efficient CO-delivery to the site of interest by conformal contacts, making it a promising scaffold for biomedical applications.
논문정보
- Research article
- 2018년 09월 (BRIC 등록일 2018-10-02)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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