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KAIST, École Polytechnique Fédérale de Lausanne

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Trends Neurosci., Published:September 07, 2018 | DOI:https://doi.org/10.1016/j.tins.2018.08.011 Neural Circuits for Goal-Directed Sensorimotor Transformations

Sylvain Crochet,^1,* Seung-Hee Lee,^1,2,* and Carl C.H. Petersen^1,*¹Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland ²Department of Biological Sciences, KAIST, Daejeon, Republic of Korea

^*Correspondence : Sylvain Crochet, Seung-Hee Lee, Carl C.H. Petersen

Abstract

Precisely wired neuronal circuits process sensory information in a learning- and context-dependent manner in order to govern behavior. Simple sensory decision-making tasks in rodents are now beginning to reveal the contributions of distinct cell types and brain regions participating in the conversion of sensory information into learned goal-directed motor output. Task learning is accompanied by target-specific routing of sensory information to specific downstream cortical regions, with higher-order cortical regions such as the posterior parietal cortex, medial prefrontal cortex, and hippocampus appearing to play important roles in learning- and context-dependent processing of sensory input. An important challenge for future research is to connect cell-type-specific activity in these brain regions with motor neurons responsible for action initiation.

Keywords : sensory perception, decision-making, neocortex, neuronal cell-types

논문정보

형식Review Paper
게재일2018년 09월 (BRIC 등록일 2018-09-13)
연구진국내(교신)+국외 연구진
분야 생명과학 > 신경생물학

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