한빛사
>
한빛사논문
구.농수식품
- 조회939
이해지Hae-Ji Lee
경희대학교
Mol. Nutr. Food Res., First published: 27 August 2018 | https://doi.org/10.1002/mnfr.201800359
Lactobacillus plantarum C29‐fermented soybean (DW2009) alleviates memory impairment in 5XFAD transgenic mice by regulating microglia activation and gut microbiota composition
Abstract
Hae-Ji Lee1, Yun-Ha Hwang2, and Dong-Hyun Kim1,*
1Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea; 2DongWha Pharm Research Institute, 35-71, Topsil-ro, Giheung-gu, Yongin-Shi, Gyeonggi 17084, Korea
*Correspondence: Prof Dong-Hyun Kim, Ph.D. College of pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
Abstract
1Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea; 2DongWha Pharm Research Institute, 35-71, Topsil-ro, Giheung-gu, Yongin-Shi, Gyeonggi 17084, Korea
*Correspondence: Prof Dong-Hyun Kim, Ph.D. College of pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
Abstract
Scope
This study was aimed to determine whether Lactobacillus plantarum C29-fermented defatted soybean (FDS, DW2009) could attenuate memory impairment in 5XFAD transgenic (Tg) mice.
Methods and results
Oral administration of FDS or C29 increased cognitive function in Tg mice in passive avoidance, Y?maze, novel object recognition, and Morris water maze tasks. FDS or C29 treatment significantly suppressed amyloid-β, β/γ-secretases, caspase-3 expression, NF-κB activation, and activated microglia and apoptotic neuron cell populations and increased BDNF expression in the brain. FDS or C29 treatment suppressed blood and fecal lipopolysaccharide levels and Enterobacteriaceae population and increased lactobacilli/bifidobacteria populations.
Conclusion
FDS and C29 alleviated the decrease in cognitive function and inhibited amyloid-β expression in Tg mice by regulating microglia activation and gut microbiota composition.
A major hallmark of Alzheimer's disease is cognitive impairment and amyloid β (Aβ) deposits in brain. In the present study, we found that Lactobacillus plantarum C29-fermented defatted soybean (FDS) and C29 alleviated cognitive function and inhibited amyloid-β expression in 5XFAD transgenic mice by regulating microglia activation and gut microbiota composition.
Keywords: Fermented defatted soybean / Lactobacillus plantarum / Memory impairment / Amyloid-β / Microglia / Lipopolysaccharide
Keywords: Fermented defatted soybean / Lactobacillus plantarum / Memory impairment / Amyloid-β / Microglia / Lipopolysaccharide
논문정보
- Research article
- 2018년 08월 (BRIC 등록일 2018-10-05)
- 국내 연구진
- 의약학 > 약학
- 구・농수식품
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
