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Trends Biochem. Sci., Published:August 20, 2018 | DOI:https://doi.org/10.1016/j.tibs.2018.08.005 Structural Insights into Polyhydroxyalkanoates Biosynthesis

Hye-Young Sagong,^1,2 Hyeoncheol Francis Son,^1,2 So Young Choi,³ Sang Yup Lee,^3,* and Kyung-Jin Kim^1,2,*¹School of Life Sciences, KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea

²KNU Institute for Microorganisms, Kyungpook National University, Daegu 41566, Republic of Korea

³Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21Plus Program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, and Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea

^*Correspondence: Sang Yup Lee, Kyung-Jin Kim

Abstract

Polyhydroxyalkanoates (PHAs) are diverse biopolyesters produced by numerous microorganisms and have attracted much attention as a substitute for petroleum-based polymers. Despite several decades of study, the detailed molecular mechanisms of PHA biosynthesis have remained unknown due to the lack of structural information on the key PHA biosynthetic enzyme PHA synthase. The recently determined crystal structure of PHA synthase, together with the structures of acetyl-coenzyme A (CoA) acetyltransferase and reductase, have changed this situation. Structural and biochemical studies provided important clues for the molecular mechanisms of each enzyme as well as the overall mechanism of PHA biosynthesis from acetyl-CoA. This new information and knowledge is expected to facilitate production of designed novel PHAs and also enhanced production of PHAs.

논문정보

형식Review Paper
게재일2018년 08월 (BRIC 등록일 2018-08-28)
연구진국내 연구진
분야 생명과학 > 생화학

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