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Neuron, Volume 99, Issue 2, p243-245, 25 July 2018 | DOI: https://doi.org/10.1016/j.neuron.2018.07.019 [Preview]Epitranscriptomes in the Adult Mammalian Brain: Dynamic Changes Regulate Behavior

Ki-Jun Yoon,¹ Guo-li Ming,^1,2,3,4 and Hongjun Song^1,2,4,5,*¹Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA

²Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA

³Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA

⁴Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

⁵The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

^*Correspondence : Hongjun Song

Abstract

Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018) , uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiological and stress-induced behaviors.

Keywords : N6-methyladenosine (m6A), epitranscriptomics, gene expression, stress, behavior, Mettl14, Mettl3, FTO

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게재일2018년 07월 (BRIC 등록일 2018-07-31)
연구진국외 연구진
분야 생명과학 > 발생생물학

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