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Alzheimers. Dement., Published online: June 21, 2018 | DOI: https://doi.org/10.1016/j.jalz.2018.05.010 Olfactory dysfunction in Alzheimer's disease– and Lewy body–related cognitive impairment

Han Soo Yoo^a,1, Seun Jeon^b,1, Seok Jong Chung^a, Alan C. Evans^b, Mijin Yun^c, Phil Hyu Lee^a, Young Ho Sohn^a, Byoung Seok Ye^a,*
^aDepartment of Neurology, Yonsei University College of Medicine, Seoul, Korea

^bMcGill Center for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, Canada

^cDepartment of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Korea
¹These authors contributed equally to this work.

^*Corresponding author : Byoung Seok Yea

Abstract

Introduction

Olfactory dysfunction is common in Alzheimer's disease? and Lewy body?related disorders, but its neural correlates have not been clearly elucidated.

Methods

We retrospectively recruited 237 patients with Alzheimer's disease?related cognitive impairment (ADCI) and 217 with Lewy body?related cognitive impairment (LBCI). They were identically evaluated using the Cross-Cultural Smell Identification Test, neuropsychological tests, and brain magnetic resonance imaging.

Results

LBCI had more severe olfactory dysfunction than ADCI. Patients with more severe cognitive dysfunction had worse olfactory function in both groups. In ADCI, lower Cross-Cultural Smell Identification Test scores correlated with a lower cortical thickness in brain regions typically affected in Alzheimer's disease, most prominently in the right parahippocampal cortex, whereas in LBCI, the scores correlated with white matter abnormalities in regions vulnerable to Lewy body, including subcortical regions of the orbitofrontal and frontoparietal cortices.

Discussion

Our results suggest that cortical atrophy in ADCI and white matter abnormalities in LBCI play important roles in olfactory dysfunction.

Keywords : Olfaction, Alzheimer's disease, Parkinson's disease, Dementia with Lewy bodies, Cognitive impairment, Cortical atrophy

논문정보

형식Research article
게재일2018년 06월 (BRIC 등록일 2018-06-29)
연구진국내(교신)+국외 연구진
분야 의약학 > 응용의학

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