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Nano Energy, Available online 7 June 2018 | https://doi.org/10.1016/j.nanoen.2018.06.015
Flexible Wireless Powered Drug Delivery System for Targeted Administration on Cerebral Cortex
Sang Hyun Sunga1, Young Soo Kimb1, Daniel J. Joea1, Beom Ho Muna, Byoung Kuk Youa,Do Hee Keumc, Sei Kwang Hahnc, Magnus Berggrend, Daesoo Kimb,*, and Keon Jae Leea*
aDepartment of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea
aDepartment of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea
bDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea
cDepartment of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Korea.
dLaboratory of Organic Electronics, Department of Science and Technology, Linkoping University, SE-601 74 Norrkoping, Sweden
1 These authors contributed equally to this work
1 These authors contributed equally to this work
*Corresponding authors
Abstract
The controlled drug delivery devices helps timely drug administrations and maintenance of effective dose to maximize curing effects with minimal side effects. Application of this technology to various body parts has been limited, especially in organs with curved surface, such as the brain and the eye. Herein, we report a flexible drug delivery microdevice (f-DDM) for controlled administration on the curved organ surface. The unique structure of the f-DDM consists of freestanding gold membranes over the multireservoir array was implemented by reversing the typical fabrication order of the reservoir and sealing membrane. We optimized the design of the f-DDM by a finite element analysis to prevent thermal damage during the laser transfer and the applying current density for reliable drug release through an electrochemical analysis. The wireless power transfer system was applied to f-DDM, which shows stable wirelessly powered operation. The f-DDM was flexible enough to be implantable on the curved cerebral cortex and successfully adopted for delivery of two different chemicals or prevention of seizure activity using an anti-epileptic drug. Our study opens a new avenue for the controlled, region-specific, and combinatorial application of drugs, the key factors for precision medicine.
KEYWORDS : drug delivery, flexible device, implantable device, wireless power transfer
논문정보
- Research article
- 2018년 09월 (BRIC 등록일 2018-06-28)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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