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Mater. Today, Available online 18 June 2018 | https://doi.org/10.1016/j.mattod.2018.05.018
Current status and outlook on the clinical translation of biodegradable metals
Hyung-Seop Han1,2, Sergio Loffredo3,4, Indong Jun1, James Edwards1, Yu-Chan Kim2,*, Hyun-Kwang Seok2, Frank Witte5, Diego Mantovani3, Sion Glyn-Jones1,*
1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK
1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK
2 Center for Biomaterials, Korea Institute of Science & Technology, Seoul 02792, Republic of Korea
3 Laboratory for Biomaterials and Bioengineering, CRC-I, Dept. Min-Met-Materials Engineering & CHU de Quebec Research Center, Laval University, Quebec City G1V 0A6, Canada
4Department of Mechanical Engineering, Politecnico di Milano, Milano 20156, Italy
5 Julius Wolff Institute and Center for Musculoskeletal Surgery, Berlin-Brandenburg Center for Regenerative Therapies, Charite-Universitatsmedizin Berlin, Berlin 13353, Germany
*Corresponding authors : Yu-Chan Kim, Sion Glyn-Jones
*Corresponding authors : Yu-Chan Kim, Sion Glyn-Jones
Abstract
During the last decade, translational research on biodegradable metallic materials has shown the feasibility of these novel materials for use in the fields of cardiology and orthopedics. Implants prepared with biodegradable metals are significantly stronger than their polymer counterparts, and there is now convincing evidence demonstrating that these materials fully biodegrade in vivo, thus reducing the need for secondary surgery. Clinical trials of such novel materials show significant potential, with the prospect of a paradigm shift in the way musculoskeletal and cardiovascular conditions are treated. This work provides an overview of the rapidly advancing technology of biodegradable metals, as well as defining some challenges in the application of these new biodegradable materials in the medical field.
논문정보
- Review Paper
- 2018년 06월 (BRIC 등록일 2018-06-22)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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