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Biol. Psychiatry, Available online 31 May 2018 | https://doi.org/10.1016/j.biopsych.2018.05.019
Microstructural Changes in Higher-order Nuclei of the Thalamus in Patients with First-episode Psychosis
Kang Ik K. Cho1,2; Yoo Bin Kwak2; Wu Jeong Hwang2; Junhee Lee3; Minah Kim3; Tae Young Lee1,3; Jun Soo Kwon1,2,3,*
1 Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea;
1 Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea;
2 Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea;
3 Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
*Corresponding Author : Professor Jun Soo Kwon Department of Psychiatry, Seoul National University College of Medicine & Brain and Cognitive Sciences, College of Natural Science, Seoul National University 101 Daehak-no, Jongno-gu, Seoul 110-744, Republic of Korea
*Corresponding Author : Professor Jun Soo Kwon Department of Psychiatry, Seoul National University College of Medicine & Brain and Cognitive Sciences, College of Natural Science, Seoul National University 101 Daehak-no, Jongno-gu, Seoul 110-744, Republic of Korea
Abstract
Background
Disruption in the thalamus, such as volume, shape and cortical connectivity, is regarded as an important pathophysiological mechanism in schizophrenia. However, there is little evidence of nuclei-specific structural alterations in the thalamus during early-stage psychosis, mainly due to the methodological limitations of conventional structural imaging in identifying the thalamic nuclei.
Methods
A total of 37 first-episode psychosis (FEP) patients and 36 matched healthy controls (HCs) underwent diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI) and T1-weighted magnetic resonance imaging. After the connectivity-based segmentation of the thalamus using DTI, averages of the diffusion kurtosis values, which represent microstructural complexity, were estimated using DKI and were compared in each thalamic nucleus between the groups.
Results
The mean kurtosis values in the thalamic regions with strong connections to the orbitofrontal cortex (F (1, 70) = 8.40, P < 0.01) and the lateral temporal cortex (F (1, 70) = 8.46, P < 0.01) were significantly reduced in FEP patients compared to those of the HCs. The mean kurtosis values in the thalamic region with strong connection to the orbitofrontal cortex showed a significant correlation with spatial working memory accuracy in FEP patients, r = 0.36, P < .05, whereas no significant correlation between these variables was observed in the HC.
Conclusions
The observed pattern of reduced microstructural complexity in the nuclei not only highlights the involvement of the thalamus but also emphasizes the role of the higher-order nuclei in the pathophysiology beginning in the early stage of schizophrenia.
Keywords: Schizophrenia, Thalamus, Mediodorsal nucleus, Pulvinar nucleus, Multimodal, Diffusion Weighted (within 6 words)
논문정보
- Research article
- 2018년 05월 (BRIC 등록일 2018-06-21)
- 국내 연구진
- 바이오·의료융합 > 뇌인지과학
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