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Adv. Drug Deliv. Rev., Available online 5 April 2018, Volume 128, Pages 29-53 | https://doi.org/10.1016/j.addr.2018.04.001 Microfluidics in nanoparticle drug delivery; From synthesis to pre-clinical screening

Jungho Ahn^a,b, Jihoon Ko^a,1, Somin Lee^c,1, JamesYu^c,1, YongTae Kim^b,d,e,f, Noo Li Jeon^a,*^aSchool of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea

^bGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332, GA, USA

^cBioengineering, Seoul National University, Seoul 151-744, Korea

^dParker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332, GA, USA

^eInstitute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta 30332, GA, USA

fWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta 30332, GA, USA
¹ Equally contributed.
^*Corresponding author.

Abstract

Microfluidic technologies employ nano and microscale fabrication techniques to develop highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead compounds can be produced with the controlled physicochemical properties, characterized in a high-throughput fashion, and evaluated in in vitro biomimetic models of human organs; organ-on-a-chip. As a step forward from conventional in vitro culture methods, microfluidics shows promise in effective preclinical testing of nanoparticle-based drug delivery. This review presents a curated selection of state-of-the-art microfluidic platforms focusing on the fabrication, characterization, and assessment of nanoparticles for drug delivery applications. We also discuss the current challenges and future prospects of nanoparticle drug delivery development using microfluidics.

Keywords :Microfluidics, Drug delivery, Nanotechnology, Nanomedicine, Organ-on-a-chip, 3D culture

논문정보

형식Review Paper
게재일2018년 04월 (BRIC 등록일 2018-06-22)
연구진국내(교신)+국외 연구진
분야 의약학 > 재생의학

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