유승식 (Harvard Medical School)

한빛사논문

조회2,425

Harvard Medical School

Curr. Biol., Vol 17, R877-R878, 23 October 2007 The human emotional brain without sleep - a prefrontal amygdala disconnect

Abstract

Seung-Schik Yoo,¹ Ninad Gujar,² Peter Hu,² Ferenc A. Jolesz,¹ and Matthew P. Walker^{2, *}

¹ Department of Radiology, Brigham and Women\''s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
² Sleep and Neuroimaging Laboratory Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720-1650, USA

*Corresponding author
Matthew P. Walker

Summary

Sleep deprivation is known to impair a range of functions, including immune regulation and metabolic control, as well as neurocognitive processes, such as learning and memory [1]. But evidence for the role of sleep in regulating our emotional brain-state is surprisingly scarce, and while the dysregulation of affective stability following sleep loss has received subjective documentation [2, 3], any neural examination remains absent. Clinical evidence suggests that sleep and emotion interact; nearly all psychiatric and neurological disorders expressing sleep disruption display corresponding symptoms of affective imbalance [4]. Independent of sleep, knowledge of the basic neural and cognitive mechanisms regulating emotion is remarkably advanced. The amygdala has a well-documented role in the processing of emotionally salient information, particularly aversive stimuli [5, 6]. The extent of amygdala engagement can also be influenced by a variety of connected systems, particularly the medial-prefrontal cortex (MPFC); the MPFC is proposed to exert an inhibitory, top-down control of amygdala function, resulting in contextually appropriate emotional responses [5, 6]. We have focused on this network and using functional magnetic resonance image (fMRI) have obtained evidence, reported here, that a lack of sleep inappropriately modulates the human emotional brain response to negative aversive stimuli (see Supplemental data available on-line with this issue).

논문정보

형식Research article
게재일2007년 10월 (BRIC 등록일 )
연구진국외 연구진
분야

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