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ACS Nano, Publication Date (Web): May 29, 2018 | DOI: 10.1021/acsnano.8b02365 Modified Magnesium Hydroxide Nanoparticles Inhibit the Inflammatory Response to Biodegradable Poly(lactide-co-glycolide) Implants

Eugene Lih^{†^}, Chang Hun Kum^{†‡^}, Wooram Park^{§^} , So Young Chun⁺, Youngjin Cho^⊥ , Yoon Ki Joung^†# , Kwang-Sook Park^†, Young Joon Hong^∇, Dong June Ahn^‡ , Byung-Soo Kim^○ , Tae Gyun Kwon^∥, Myung Ho Jeong^∇, Jeffrey A. Hubbell^*& , and Dong Keun Han^*§^†Center for Biomaterials, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea

^‡ Department of Chemical & Biological Engineering and KU-KIST Graduate School of Converging Science & Technology, Korea University, Seoul 02841, Republic of Korea

^§Department of Biomedical Science, College of Life Sciences, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi 13488, Republic of Korea

⁺ BioMedical Research Institute, Kyungpook National University Hospital, Daegu 41944, Republic of Korea

^∥ Department of Urology, School of Medicine, Kyungpook National University, Daegu 37224, Republic of Korea

^⊥ Research Group of Food Storage & Distribution, Korea Food Research Institute, Wanju 55365, Republic of Korea

^# Department of Biomedical Engineering, Korea University of Science and Technology, Daejeon 34113, Republic of Korea

^∇ The Heart Center of Chonnam National University Hospital, Gwangju 61469, Republic of Korea

^○ School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Republic of Korea

^& Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States

Author Contributions
^{^}E.L., C.H.K., and W.P. contributed equally.

^*Corresponding Authors

Abstract

Biodegradable polymers have been extensively used in biomedical applications, ranging from regenerative medicine to medical devices. However, the acidic byproducts resulting from degradation can generate vigorous inflammatory reactions, often leading to clinical failure. We present an approach to prevent acid-induced inflammatory responses associated with biodegradable polymers, here poly(lactide-co-glycolide), by using oligo(lactide)-grafted magnesium hydroxide (Mg(OH)₂) nanoparticles, which neutralize the acidic environment. In particular, we demonstrated that incorporating the modified Mg(OH)₂ nanoparticles within degradable coatings on drug-eluting arterial stents efficiently attenuates the inflammatory response and in-stent intimal thickening by more than 97 and 60%, respectively, in the porcine coronary artery, compared with that of drug-eluting stent control. We also observed that decreased inflammation allows better reconstruction of mouse renal glomeruli in a kidney tissue regeneration model. Such modified Mg(OH)₂ nanoparticles may be useful to extend the applicability and improve clinical success of biodegradable devices used in various biomedical fields.

Keywords: biodegradable polymers; biomedical applications; inflammation; magnesium hydroxide; neutralization

논문정보

형식Research article
게재일2018년 05월 (BRIC 등록일 2018-06-20)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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