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Princeton University

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Cell, Volume 173, Issue 5, p1293-1306.e19, 17 May 2018 | DOI: https://doi.org/10.1016/j.cell.2018.04.040 Digital Museum of Retinal Ganglion Cells with Dense Anatomy and Physiology

J. Alexander Bae,^1,2,11 Shang Mu,^1,11 Jinseop S. Kim,^1,9,11 Nicholas L. Turner,^1,3,11 Ignacio Tartavull,¹ Nico Kemnitz,¹ Chris S. Jordan,⁴ Alex D. Norton,⁴ William M. Silversmith,⁴ Rachel Prentki,⁴ Marissa Sorek,⁴ Celia David,⁴ Devon L. Jones,⁴ Doug Bland,⁴ Amy L.R. Sterling,⁴ Jungman Park,⁵ Kevin L. Briggman,^6,7,10 H. Sebastian Seung,^1,3,12,* and the Eyewirers⁸¹Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA

²Electrical Engineering Department, Princeton University, Princeton, NJ 08544, USA

³Computer Science Department, Princeton University, Princeton, NJ 08540, USA

⁴WiredDifferently, Inc., 745 Atlantic Ave, Boston, MA 02111, USA

⁵Device Business Unit, Marketing Group, KT Gwanghwamun Bldg. West, 178, Sejong-daero, Jongno-gu, Seoul 03154, Republic of Korea

⁶Department of Biomedical Optics, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany

⁷Circuit Dynamics and Connectivity Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA

⁸https://eyewire.org

⁹Present address: Department of Structure and Function of Neural Networks, Korea Brain Research Institute, Daegu 41068, Republic of Korea

¹⁰Present address: Center of Advanced European Studies and Research (caesar), Department of Computational Neuroethology,

53175 Bonn, Germany

¹¹These authors contributed equally

¹²Lead Contact

^*Correspondence : H. Sebastian Seung

Abstract

When 3D electron microscopy and calcium imaging are used to investigate the structure and function of neural circuits, the resulting datasets pose new challenges of visualization and interpretation. Here, we present a new kind of digital resource that encompasses almost 400 ganglion cells from a single patch of mouse retina. An online “museum” provides a 3D interactive view of each cell’s anatomy, as well as graphs of its visual responses. The resource reveals two aspects of the retina’s inner plexiform layer: an arbor segregation principle governing structure along the light axis and a density conservation principle governing structure in the tangential plane. Structure is related to visual function; ganglion cells with arbors near the layer of ganglion cell somas are more sustained in their visual responses on average. Our methods are potentially applicable to dense maps of neuronal anatomy and physiology in other parts of the nervous system.

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형식Research article
게재일2018년 05월 (BRIC 등록일 2018-05-24)
연구진국내+국외 연구진
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