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한빛사논문
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Science, 27 Apr 2018 : Vol. 360, Issue 6387, pp. 430-435 | DOI: 10.1126/science.aas9204
Interregional synaptic maps among engram cells underlie memory formation
Jun-Hyeok Choi,* Su-Eon Sim,* Ji-il Kim,* Dong Il Choi,* Jihae Oh, Sanghyun Ye, Jaehyun Lee, TaeHyun Kim, Hyoung-Gon Ko, Chae-Seok Lim, Bong-Kiun Kaang†
School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
†Corresponding author.
*These authors contributed equally to this work.
School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
†Corresponding author.
*These authors contributed equally to this work.
Abstract
Memory resides in engram cells distributed across the brain. However, the site-specific substrate within these engram cells remains theoretical, even though it is generally accepted that synaptic plasticity encodes memories. We developed the dual-eGRASP (green fluorescent protein reconstitution across synaptic partners) technique to examine synapses between engram cells to identify the specific neuronal site for memory storage. We found an increased number and size of spines on CA1 engram cells receiving input from CA3 engram cells. In contextual fear conditioning, this enhanced connectivity between engram cells encoded memory strength. CA3 engram to CA1 engram projections strongly occluded long-term potentiation. These results indicate that enhanced structural and functional connectivity between engram cells across two directly connected brain regions forms the synaptic correlate for memory formation.
논문정보
TOP52018년 선정
- Research article
- 2018년 04월 (BRIC 등록일 2018-05-02)
- 국내 연구진
- 생명과학 > 신경생물학
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