Donna M. Werling^1,28, Harrison Brand^2,3,4,28, Joon-Yong An^1,28, Matthew R. Stone^2,28, Lingxue Zhu^5,28, Joseph T. Glessner^2,3,4, Ryan L. Collins^2,3,6, Shan Dong¹, Ryan M. Layer^7,8, Eirene Markenscoff-Papadimitriou¹, Andrew Farrell^7,8, Grace B. Schwartz¹, Harold Z. Wang², Benjamin B. Currall^2,3,4, Xuefang Zhao^2,3,4, Jeanselle Dea¹, Clif Duhn¹, Carolyn A. Erdman¹, Michael C. Gilson1, Rachita Yadav^2,3,4, Robert E. Handsaker ^4,9, Seva Kashin^4,9, Lambertus Klei¹⁰, Jeffrey D. Mandell¹, Tomasz J. Nowakowski^1,11,12, Yuwen Liu¹³, Sirisha Pochareddy¹⁴, Louw Smith¹, Michael F. Walker¹, Matthew J. Waterman¹⁵, Xin He¹³, Arnold R. Kriegstein¹⁶, John L. Rubenstein¹, Nenad Sestan¹⁴, Steven A. McCarroll^4,9, Benjamin M. Neale^4,17,18, Hilary Coon^19,20, A. Jeremy Willsey^1,21, Joseph D. Buxbaum^22,23,24,25, Mark J. Daly^4,17,18, Matthew W. State¹, Aaron R. Quinlan ^7,8,20, Gabor T. Marth^7,8, Kathryn Roeder^5,26, Bernie Devlin^10*, Michael E. Talkowski ^2,3,4,27* and Stephan J. Sanders<sup>1*

1</sup>Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. ²Center for Genomic Medicine and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. ³Department of Neurology, Harvard Medical School, Boston, MA, USA. ⁴Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA. ⁵Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA. ⁶Program in Bioinformatics and Integrative Genomics, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA. ⁷Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA. ⁸USTAR Center for Genetic Discovery, University of Utah School of Medicine, Salt Lake City, UT, USA. ⁹Department of Genetics, Harvard Medical School, Boston, MA, USA. ¹⁰Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ¹¹Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA. ¹²Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA. ¹³Department of Human Genetics, University of Chicago, Chicago, IL, USA. ¹⁴Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA. ¹⁵Department of Biology, Eastern Nazarene College, Quincy, MA, USA. ¹⁶Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. ¹⁷Analytical and Translational Genetics Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. ¹⁸Department of Medicine, Harvard Medical School, Boston, MA, USA. ¹⁹Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA. ²⁰Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT, USA. ²¹Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. ²²Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ²³Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ²⁴Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ²⁵Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ²⁶Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA, USA. ²⁷Departments of Pathology and Psychiatry, Massachusetts General Hospital, Boston, MA, USA. ²⁸These authors contributed equally: Donna M. Werling, Harrison Brand, Joon-Yong An, Matthew R. Stone,Lingxue Zhu.

Correspondence to Bernie Devlin or Michael E. Talkowski or Stephan J. Sanders