한빛사
>
한빛사논문
한빛사논문
- 조회2,244
Nat. Neurosci., Published online:29 January 2018, doi:10.1038/s41593-018-0072-x
Medial preoptic circuit induces hunting-like actions to target objects and prey
Sae-Geun Park1,3, Yong-Cheol Jeong1,3, Dae-Gun Kim1,2,3, Min-Hyung Lee1, Anna Shin1, Geunhong Park1, Jia Ryoo1, Jiso Hong1, Seohui Bae1, Cheol-Hu Kim2, Phill-Seung Lee 2,* and Daesoo Kim1,*
1Department of Biological Sciences, KAIST, Daejeon, Korea. 2Department of Mechanical Engineering, KAIST, Daejeon, Korea. 3These authors contributed equally: Sae-Geun Park, Yong-Cheol Jeong and Dae-Gun Kim.
*Corresponding authors
Abstract
As animals forage, they must obtain useful targets by orchestrating appropriate actions that range from searching to chasing, biting and carrying. Here, we reveal that neurons positive for the α subunit of Ca2+/calmodulin-dependent kinase II (CaMKIIα) in the medial preoptic area (MPA) that send projections to the ventral periaqueductal gray (vPAG) mediate these target-directed actions in mice. During photostimulation of the MPA–vPAG circuit, mice vigorously engaged with 3D objects and chased moving objects. When exposed to a cricket, they hunted down the prey and bit it to kill. By applying a head-mounted object control with timely photostimulation of the MPA–vPAG circuit, we found that MPA–vPAG circuit-induced actions occurred only when the target was detected within the binocular visual field. Using this device, we successfully guided mice to navigate specified routes. Our study explains how the brain yields a strong motivation to acquire a target object along the continuum of hunting behavior.
논문정보
- Research article
- 2018년 01월 (BRIC 등록일 2018-02-13)
- 국내 연구진
- 생명과학 > 신경생물학
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
