윤주영 (이화여자대학교)

한빛사논문

조회1,512

이화여자대학교

ACS Nano, Publication Date (Web): December 12, 2017 | DOI: 10.1021/acsnano.7b07809 Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy

Xingshu Li^†‡⊥, Sungsook Yu^§⊥, Dayoung Lee^‡⊥, Gyoungmi Kim^‡, Buhyun Lee^§, Yejin Cho^§, Bi-Yuan Zheng^†, Mei-Rong Ke^†, Jian-Dong Huang^*†, Ki Taek Nam^*§, Xiaoyuan Chen^*∥, and Juyoung Yoon^*‡

^† College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China

^‡ Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, South Korea

^§ Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, College of Medicine, Yonsei University, Seoul 120-752, South Korea

^∥ Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States

^*Corresponding Authors

Author Contributions
^⊥X.L., S.Y., and D.L. contributed equally.

Abstract

Supramolecular chemistry provides a “bottom-up” method to fabricate nanostructures for biomedical applications. Herein, we report a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which not only display nanoscale optical properties but also have the capability of undergoing nucleic-acid-responsive disassembly. These supramolecular assemblies possess activatable fluorescence emission and singlet oxygen generation associated with the formation of free PcS, mild photothermal heating, and a concomitant chemotherapeutic effect associated with the formation of free MA. In vivo evaluations indicate that PcS-MA nanostructures have a high level of accumulation in tumor tissues, are capable of being used for cancer imaging, and have significantly improved anticancer effect compared to that of PcS. This study demonstrates an attractive strategy for overcoming the limitations of photodynamic cancer therapy.

Keywords: activatable; nanotheranostics; nucleic-acid-responsive disassembly; photodynamic therapy; supramolecular assembly

논문정보

형식Research article
게재일2017년 12월 (BRIC 등록일 2018-01-12)
연구진국내(교신)+국외 연구진
분야 의약학 > 응용의학

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