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Adv. Funct. Mater., Volume 27, Issue 45, December 1, 2017 | DOI: 10.1002/adfm.201704213
Enzyme-Driven Hasselback-Like DNA-Based Inorganic Superstructures
Jae Sung Lee1, Hyejin Kim1, Changshin Jo2, Jaepil Jeong1, Jeonghyun Ko1, Sangwoo Han1, Min Sun Lee3,4, Ho-Young Lee3,4, Jeong Woo Han1, Jinwoo Lee2 and Jong Bum Lee1,*
1Department of Chemical Engineering, University of Seoul, Seoul, South Korea
1Department of Chemical Engineering, University of Seoul, Seoul, South Korea
2Department of Chemical Engineering, Pohang University of Science and Technology, Kyungbuk, South Korea
3Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea
4Cancer Research Institute, Seoul National University, Seoul, South Korea
J.S.L. and H.K. contributed equally to this work.
*To whom correspondence may be addressed.
J.S.L. and H.K. contributed equally to this work.
*To whom correspondence may be addressed.
Abstract
DNA structures have gained much attention due to its ease of self-assembly and precise controllability. Although DNA technology has been successfully applied to generate a variety of DNA structures, there are only few attempts to apply DNA technology to generate inorganic materials due to lack of controllability of interactions between DNA and inorganic materials. In addition, the synthesis of a predictable structure of hybrid materials still remains a significant challenge. To address the challenge, here a novel strategy for the synthesis of DNA-based inorganic superstructures using DNA polymerase is reported. In particular, strategic feeding of metal ions for generating DNA-inorganic hybrid superstructures during DNA polymerization is established. This approach can produce a variety of structures with varying metal ions and can easily add functionality to the product. The structural features are also easily studied by first-principles calculations. With these advantages, DNA-Mn particles show the potential as a cell tracking agent, a contrast agent for MRI, and an electrode material for supercapacitors. The enzyme-driven synthesis in this study will provide a novel route for the generation of a range of organic-inorganic hybrid superstructures for biomedical and energy applications.
Keywords : DNA; enzymatic synthesis; organic-inorganic hybrid composites; rolling circle amplification
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- Research article
- 2017년 12월 (BRIC 등록일 2017-12-08)
- 국내 연구진
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