조일주 (한국과학기술연구원, UST)

한빛사논문

조회1,880

한국과학기술연구원, UST

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Adv. Drug Deliv. Rev., Available online 5 November 2017 | https://doi.org/10.1016/j.addr.2017.11.003 MEMS devices for drug delivery

Hyunjoo J. Lee^a, Nakwon Choi^{b, c}, Eui-Sung Yoon^b, Il-Joo Cho^{b, c, *}^a School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea

^b Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea

^c Division of Bio-Medical Science & Technology (Biomedical Engineering), KIST School, Korea University of Science and Technology (UST), Daejeon, 34113, Republic of Korea

^*Corresponding author : Il-Joo Cho

Abstract

Novel drug delivery systems based on microtechnology have advanced tremendously, but yet face some technological and societal hurdles to fully achieve their potential. The novel drug delivery systems aim to deliver drugs in a spatiotemporal- and dosage-controlled manner with a goal to address the unmet medical needs from oral delivery and hypodermic injection. The unmet needs include effective delivery of new types of drug candidates that are otherwise insoluble and unstable, targeted delivery to areas protected by barriers (e.g. brain and posterior eye segment), localized delivery of potent drugs, and improved patient compliance. After scrutinizing the design considerations and challenges associated with delivery to areas that cannot be efficiently targeted through standard drug delivery (e.g. brain, posterior eye segment, and gastrointestinal tract), this review provides a summary of recent advances that addressed these challenges and summarizes yet unresolved problems in each target area. The opportunities for innovation in devising the novel drug delivery systems are still high; with integration of advanced microtechnology, advanced fabrication of biomaterials, and biotechnology, the novel drug delivery is poised to be a promising alternative to the oral administration and hypodermic injection for a large spectrum of drug candidates.

Keywords : brain infusion; blood-brain barrier (BBB) disruption; capsule endoscope; implantable drug delivery; microneedles; transdermal drug delivery

논문정보

형식Review Paper
게재일2017년 11월 (BRIC 등록일 2017-11-17)
연구진국내 연구진
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