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기초과학연구원, POSTECH

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Adv. Mater., Version of Record online: 11 OCT 2017 | DOI: 10.1002/adma.201702859 Therapeutic-Gas-Responsive Hydrogel

Junghong Park^1,2, Swapan Pramanick^1,2, Dongsik Park^1,2, Jiwon Yeo^1,2, Jihyun Lee^1,2, Haeshin Lee³ and Won Jong Kim^1,2,*¹Center for Self-Assembly and Complexity, Institute for Basic Science (IBS), Pohang, Republic of Korea

²Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea

³Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

^*Corresponding author

Abstract

Nitric oxide (NO) is a crucial signaling molecule with various functions in physiological systems. Due to its potent biological effect, the preparation of responsive biomaterials upon NO having temporally transient properties is a challenging task. This study represents the first therapeutic-gas (i.e., NO)-responsive hydrogel by incorporating a NO-cleavable crosslinker. The hydrogel is rapidly swollen in response to NO, and not to other gases. Furthermore, the NO-responsive gel is converted to enzyme-responsive gels by cascade reactions from an enzyme to NO production for which the NO precursor is a substrate of the enzyme. The application of the hydrogel as a NO-responsive drug-delivery system is proved here by revealing effective protein drug release by NO infusion, and the hydrogel is also shown to be swollen by the NO secreted from the cultured cells. The NO-responsive hydrogel may prove useful in many applications, for example drug-delivery vehicles, inflammation modulators, and as a tissue scaffold.

Keywords: gas-absorbing materials; hydrogels; nitric oxide; stimuli-responsive materials

논문정보

형식Research article
게재일2017년 10월 (BRIC 등록일 2017-10-17)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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