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Max Planck Institute for Intelligent Systems

ACS Nano, Publication Date (Web): September 21, 2017 | DOI: 10.1021/acsnano.7b04128 Magnetotactic Bacteria Powered Biohybrids Target E. coli Biofilms

Morgan M. Stanton^†‡# , Byung-Wook Park^‡#, Diana Vilela^†⊥ , Klaas Bente^§, Damien Faivre^*§ , Metin Sitti^*‡ , and Samuel Sanchez^*†∥⊥^† Lab-in-a-Tube and Nanorobotic Biosensors, Max Planck Institute for Intelligent Systems, Heisenbergstraße 3, 70569 Stuttgart, Germany

^‡ Physical Intelligence Department, Max Planck Institute for Intelligent Systems, Heisenbergstraße 3, 70569 Stuttgart, Germany

^§ Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Science Park Golm, Am Muhlenberg 1, 14476 Potsdam, Germany

^∥ Institucio Catalana de Recerca i EstudisAvancats (ICREA), Pg. Lluis Companys 23, 08010 Barcelona, Spain

^⊥ Smart Nano-Bio-Devices, Institute for Bioengineering of Catalonia (IBEC), Baldiri i Reixac 10?12, 08028 Barcelona, Spain

^*Corresponding Authors

Author Contributions
^#M. M. Stanton and B.-W. Park contributed equally to this publication.

Abstract

Biofilm colonies are typically resistant to general antibiotic treatment and require targeted methods for their removal. One of these methods includes the use of nanoparticles as carriers for antibiotic delivery, where they randomly circulate in fluid until they make contact with the infected areas. However, the required proximity of the particles to the biofilm results in only moderate efficacy. We demonstrate here that the nonpathogenic magnetotactic bacteria Magnetosopirrillum gryphiswalense (MSR-1) can be integrated with drug-loaded mesoporous silica microtubes to build controllable microswimmers (biohybrids) capable of antibiotic delivery to target an infectious biofilm. Applying external magnetic guidance capability and swimming power of the MSR-1 cells, the biohybrids are directed to and forcefully pushed into matured Escherichia coli (E. coli) biofilms. Release of the antibiotic, ciprofloxacin, is triggered by the acidic microenvironment of the biofilm, ensuring an efficient drug delivery system. The results reveal the capabilities of a nonpathogenic bacteria species to target and dismantle harmful biofilms, indicating biohybrid systems have great potential for antibiofilm applications.

Keywords: antibiotic; biofilm; biohybrid; E. coli; magnetotatic bacteria; mesoporous silica

논문정보

형식Research article
게재일2017년 09월 (BRIC 등록일 2017-10-12)
연구진국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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