상위피인용논문
- 조회472
Eun Jung Cha,1 Sang Jae Noh,1 Keun Sang Kwon,2 ChanYoung Kim,3 Byung-Hyun Park,4 Ho Sung Park,1 Ho Lee,5 Myoung Ja Chung,1 Myoung Jae Kang,1 Dong Geun Lee,1 Woo Sung Moon,1,* and KyuYun Jang1,*
Authors’Affiliations: Departments of 1 Pathology, 2 Preventive Medicine, 3 General Surgery, 4 Biochemistry, and 5 Forensic Medicine, Research Institute of Clinical Medicine and Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeonbuk, Republic of Korea
*Requests for reprints: Kyu Yun Jang and Woo Sung Moon, Department of Pathology, Chonbuk National University Medical School, San 2-20 Keumamdong, Dukjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea.
Abstract
Purpose: SIRT1 (silent mating-type information regulation 2 homologue 1) expression has been reported to predict poor survival in some cancers. We therefore investigated the expression levels of SIRT1 and its negative regulator, DBC1 (deleted in breast cancer 1), in gastric cancer patients.
Experimental Design: We evaluated immunohistochemical expression of DBC1, SIRT1, and p53 using 3-mm tumor cores from 177 gastric cancer patients for tissue microarray.
Results: Positive expressions of DBC1 and SIRT1 were seen in 62% (109 of 177) and in 73% (130 of 177) of patients, respectively. Expression of DBC1 was significantly correlated with tumor stage (P = 0.007), lymph node metastasis (P < 0.001), tumor invasion (P = 0.001), venous invasion (P = 0.001), histologic types (P < 0.001), p53 expression (P < 0.001), and SIRT1 expression (P < 0.001). SIRT1 expression was also significantly correlated with tumor stage (P < 0.001), lymph node metastasis (P < 0.001), tumor invasion (P < 0.001), histologic types (P < 0.001), and p53 expression (P = 0.001). In addition, expression of DBC1 was significantly associated with shorter overall survival and relapse-free survival by univariate analysis (P < 0.001 and P < 0.001, respectively). SIRT1 expression was also significantly associated with shorter overall survival and relapse-free survival by univariate analysis (P = 0.001 and P = 0.001, respectively). Multivariate analysis showed that tumor stage and expression of DBC1 were independent prognostic factors significantly associated with overall survival and relapse-free survival.
Conclusion: This study shows that expression of DBC1 and SIRT1 is a significant prognostic indicator for gastric carcinoma patients.
논문정보
- Research article
- 2009년 07월 (BRIC 등록일 2017-08-23)
- 국내 연구진
- 120회 이상 인용된 논문
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