한빛사논문
- 조회1,775
Taehong Yang1, Cindy F. Yang5, 8, M. Delara Chizari6, 9, Niru Maheswaranathan2, Kenneth J. Burke Jr.5, Maxim Borius6, 10, Sayaka Inoue1, Michael C. Chiang6, 11, Kevin J. Bender7, Surya Ganguli3, 4, Nirao M. Shah1, 4, 12
1 Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
2 Program in Neuroscience, Stanford University, Stanford, CA 94305, USA
3 Department of Applied Physics, Stanford University, Stanford, CA 94305, USA
4 Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
5 Program in Neuroscience, UC San Francisco, San Francisco, CA 94158, USA
6 Department of Anatomy, UC San Francisco, San Francisco, CA 94158, USA
7 Department of Neurology, UC San Francisco, San Francisco, CA 94158, USA
8 Present address: Department of Neurobiology, UC Los Angeles, Los Angeles, CA 90095, USA
9 Present address: Program in Neuroscience, Harvard University, Boston, MA 02115, USA
10 Present address: SpikeGadgets, San Francisco, CA 94107, USA
11 Present address: University of Pittsburgh, MSTP, Pittsburgh, PA 15213, USA
12 Lead Contact
Corresponding author : Nirao M. Shah
Abstract
How environmental and physiological signals interact to influence neural circuits underlying developmentally programmed social interactions such as male territorial aggression is poorly understood. We have tested the influence of sensory cues, social context, and sex hormones on progesterone receptor (PR)-expressing neurons in the ventromedial hypothalamus (VMH) that are critical for male territorial aggression. We find that these neurons can drive aggressive displays in solitary males independent of pheromonal input, gonadal hormones, opponents, or social context. By contrast, these neurons cannot elicit aggression in socially housed males that intrude in another male’s territory unless their pheromone-sensing is disabled. This modulation of aggression cannot be accounted for by linear integration of environmental and physiological signals. Together, our studies suggest that fundamentally non-linear computations enable social context to exert a dominant influence on developmentally hard-wired hypothalamus-mediated male territorial aggression.
Keywords : aggression; territorial behavior; sexual dimorphism; emotion; progesterone receptor; sex hormones; castration; pheromone; ventromedial hypothalamus; VMH
논문정보
- Research article
- 2017년 07월 (BRIC 등록일 2017-08-03)
- 국외 연구진
- 생명과학 > 생리학
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