한빛사논문
- 조회2,367
Ji Won Um1, Jaewon Ko1
1 Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea
Correspondence : Ji Won Um, Jaewon Ko
Abstract
Glycosylphosphatidylinositol (GPI)-anchored proteins are a specialized class of lipid-associated neuronal membrane proteins that perform diverse functions in the dynamic control of axon guidance, synaptic adhesion, cytoskeletal remodeling, and localized signal transduction, particularly at lipid raft domains. Recent studies have demonstrated that a subset of GPI-anchored proteins act as critical regulators of synapse development by modulating specific synaptic adhesion pathways via direct interactions with key synapse-organizing proteins. Additional studies have revealed that alteration of these regulatory mechanisms may underlie various brain disorders. In this review, we highlight the emerging role of GPI-anchored proteins as key synapse organizers that aid in shaping the properties of various types of synapses and circuits in mammals.
Keywords : GPI; synapse; neural circuit; synaptic adhesion; lipid raft
논문정보
- Review Paper
- 2017년 07월 (BRIC 등록일 2017-07-26)
- 국내 연구진
- 생명과학 > 신경생물학
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