구.농수식품
- 조회1,222
Abstract
Dong-Hee Choa, Jin-Sol Baea, Ji-Min Jeonga, Hyun-Ja Hanb, Deok Chan Leeb, Mi Young Chob, Sung Hee Jungb, Do-Hyung Kimc, *, Chan-Il Parka, *
a Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University, 455, Tongyeong, 650-160, Republic of Korea
b Pathology Research Division, National Institute of Fisheries Science, 408-1 Sirang-ri, Gijang-up, Gijang-gun, Busan 46083, Republic of Korea
c Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University, 45, Yongso-ro, Nam-Gu., Busan, Republic of Korea
*Corresponding author : Do-Hyung Kimc, Chan-Il Park
Abstract
CD2 is expressed on the surfaces of virtually all T cells and natural killer (NK) cells. In mammals, the CD2 molecule is 50 kDa. The cytoplasmic tail of CD2 interacts with CD2-associated protein (CD2AP), which plays an important role in mediating the trigger signal in outer magnetic pole cells. In this study, we identified CD2AP from rock bream and investigated its gene expression. The ORF of CD2AP (1950 bp) encodes 650 amino acids (aa). CD2AP has a Src homology 3 (SH3) domain. Quantitative real-time PCR analysis revealed that CD2AP shows higher expression in the gills and skin. Under experimental challenge, CD2AP gene expression was increased as relative to the control after 7 days. This result will improve our understanding of blood vessels in teleost fish, and will provide a basis for the study of CD2-related genes.
Keywords : Rock bream; CD2-Associated protein; T cells; SH3 domain; Gene expression
논문정보
- Research article
- 2017년 05월 (BRIC 등록일 2017-05-26)
- 국내 연구진
- 구・농수식품
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