김형 (성균관대학교, 기초과학연구원)

한빛사논문

조회2,489

성균관대학교, 기초과학연구원

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Neuron, Volume 94, Issue 4, 17 May 2017, Pages 920-930.e3, https://doi.org/10.1016/j.neuron.2017.04.033 Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects

Hyoung F. Kim,^1,2,5,* Hidetoshi Amita,³ and Okihide Hikosaka^3,4¹Department of Biomedical Engineering, Sungkyunkwan University (SKKU)

²Center for Neuroscience Imaging Research, Institute for Basic Science (IBS) Suwon 16419, Republic of Korea

³Laboratory of Sensorimotor Research, National Eye Institute

⁴National Institute on Drug Abuse National Institutes of Health, Bethesda, MD 20892, USA

⁵Lead Contact
^*Correspondence

Abstract

The striatum controls behavior in two ways: facilitation and suppression through the direct and indirect pathways, respectively. However, it is still unclear what information is processed in these pathways. To address this question, we studied two pathways originating from the primate caudate tail (CDt). We found that the CDt innervated the caudal-dorsal-lateral part of the substantia nigra pars reticulata (cdlSNr), directly or indirectly through the caudal-ventral part of the globus pallidus externus (cvGPe). Notably, cvGPe neurons receiving inputs from the CDt were mostly visual neurons that encoded stable reward values of visual objects based on long-past experiences. Their dominant response was inhibition by valueless objects, which generated disinhibition of cdlSNr neurons and inhibition of superior colliculus neurons. Our data suggest that low-value signals are sent by the CDt-indirect pathway to suppress saccades to valueless objects, whereas high-value signals are sent by the CDt-direct pathway to facilitate saccades to valuable objects.

Keywords:

Basal ganglia, Globus pallidus external segment, Striatum, Macaque monkey, Indirect pathway, Direct pathway, Decision-making, Long-term memory, Reward value, Visual object

논문정보

형식Research article
게재일2017년 05월 (BRIC 등록일 2017-05-23)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 뇌인지과학

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