한빛사논문
- 조회1,706
National University of Singapore, Agency for Science, Technology and Research, 현 POSTECH
Dr. Juanjuan Peng1,2,†,*, Dr. Animesh Samanta2,†, Xiao Zeng3, Dr. Sanyang Han3,5, Lu Wang3, Dr. Dongdong Su2, Dr. Daniel Teh Boon Loong4, Dr. Nam-Young Kang2, Dr. Sung-Jin Park2, Prof. Angelo Homayoun All5,6, Wenxuan Jiang5, Prof. Lin Yuan3,7,*, Prof. Xiaogang Liu3,8,* and Prof. Young-Tae Chang2,3,*
1 State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Jiangsu, China
2 Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A* STAR), Singapore, Singapore
3 Department of Chemistry, National University of Singapore, Singapore, Singapore
4 Singapore Institute of Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore
5 Department of Orthopedic Surgery, National University of Singapore, Singapore, Singapore
6 Departments of Biomedical Engineering and Neurology, Johns Hopkins University, Baltimore, USA
7 State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering, Hunan University, Hunan, China
8 Institute of Materials Research and Engineering, Agency for Science Technology and Research (A* STAR), Singapore, Singapore
† These authors contributed equally to this work.
*Corresponding authors
Abstract
Drug toxicity is a long-standing concern of modern medicine. A typical anti-pain/fever drug paracetamol often causes hepatotoxicity due to peroxynitrite ONOO-. Conventional blood tests fail to offer real-time unambiguous visualization of such hepatotoxicity in vivo. Here we report a luminescent approach to evaluate acute hepatotoxicity in vivo by chromophore-conjugated upconversion nanoparticles. Upon injection, these nanoprobes mainly accumulate in the liver and the luminescence of nanoparticles remains suppressed owing to energy transfer to the chromophore. ONOO- can readily bleach the chromophore and thus recover the luminescence, the presence of ONOO- in the liver leads to fast restoring of the near-infrared emission. Taking advantages of the high tissue-penetration capability of near-infrared excitation/emission, these nanoprobes achieve real-time monitoring of hepatotoxicity in living animals, thereby providing a convenient screening strategy for assessing hepatotoxicity of synthetic drugs.
Keywords: biosensors; fluorescent probes; hepatotoxicity; nanotechnology; paracetamol
논문정보
- Research article
- 2017년 04월 (BRIC 등록일 2017-05-08)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
