한빛사 논문
- 조회1,717
Abstract
Do-Hyoung Kim1†, Minjung Shin1†, Sung-Hwan Jung2, Young-Joon Kim2, Walton D. Jones1*
1 Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea, 2 School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea
†These authors contributed equally to this work
*Corresponding authors
Abstract
Here, we show that the enzymatic cofactor tetrahydrobiopterin (BH4) inhibits feeding in Drosophila. BH4 biosynthesis requires the sequential action of the conserved enzymes Punch, Purple, and Sepiapterin Reductase (Sptr). Although we observe increased feeding upon loss of Punch and Purple in the adult fat body, loss of Sptr must occur in the brain. We found Sptr expression is required in four adult neurons that express neuropeptide F (NPF), the fly homologue of the vertebrate appetite regulator neuropeptide Y (NPY). As expected, feeding flies BH4 rescues the loss of Punch and Purple in the fat body and the loss of Sptr in NPF neurons. Mechanistically, we found BH4 deficiency reduces NPF staining, likely by promoting its release, while excess BH4 increases NPF accumulation without altering its expression. We thus show that, because of its physically distributed biosynthesis, BH4 acts as a fat-derived signal that induces satiety by inhibiting the activity of the NPF neurons.
논문정보
- Research article
- 2017년 03월 (BRIC 등록일 2017-03-30)
- 국내 연구진
- 생명과학 > 세포생물학
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