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Food Chem., Available online 22 March 2017 | http://dx.doi.org/10.1016/j.foodchem.2017.03.107 Investigation of the antioxidant and aldose reductase inhibitory activities of extracts from Peruvian tea plant infusions

Abstract

Zhiqiang Wang^{a, 1}, Seung Hwan Hwang^{a, 1}, Yanymee N. Guillen Quispe^a, Paul H. Gonzales Arce^d, Soon Sung Lim^{a, b, c,*}^a Department of Food Science and Nutrition, Hallym University, 1 Hallymdeahak-gil, Chuncheon, 24252, Republic of Korea
^b Institute of Natural Medicine, Hallym University, 1 Hallymdeahak-gil, Chuncheon, 24252, Republic of Korea
^c Institute of Korean Nutrition, Hallym University, 1 Hallymdeahak-gil, Chuncheon, 24252, Republic of Korea
^d Laboratorio de Floristica, Departamento de Dicotiledoneas, Museo de Historia Natural - Universidad Nacional Mayor de San Marcos, Avenida Arenales 1256, Lima, 14-0434, Republic of Peru

^*Corresponding author

¹Z Wang and SH Hwang contributed equally to this work.

Abstract
In the present study, the antioxidant and aldose reductase inhibitory activities of 24 Peruvian infusion tea plants were investigated by 2,2’-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and aldose reductase assays. Phoradendron sp. showed the highest inhibition of aldose reductase (IC₅₀, 1.09 ± 0.06 μg/mL) and considerable antioxidant (IC₅₀ of DPPH, 58.36 ± 1.65 μg/mL; IC₅₀ of ABTS, 9.91 ± 0.43 μg/mL) effects. In order to identify the antioxidants and aldose reductase inhibitors of Phoradendron sp., DPPH-high performance liquid chromatography (HPLC) and ultrafiltration-HPLC assays were performed. Chlorogenic acid, 3,5-di-O-caffeoylquinic acid, and 1,3,5-tri-O-caffeoylquinic acid were identified as the antioxidants and aldose reductase inhibitors; apigenin was identified as the antioxidant. Finally, Phoradendron sp. and its aldose reductase inhibitors also showed a dose-dependent anti-inflammatory effect without cellular toxicity. These results suggested that Phoradendron sp. can be a potent functional food ingredient as an antioxidant, aldose reductase inhibitor and anti-inflammatory agent.

Keywords : Peruvian infusion tea plants; Phoradendron sp.; Antioxidant; Aldose reductase; Anti-inflammation

논문정보

형식Research article
게재일2017년 03월 (BRIC 등록일 2017-03-27)
연구진국내(교신)+국외 연구진
분야 생명과학 > 식품학
구분구・농수식품

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