최지현 (한국과학기술연구원, UST) | 한빛사논문 > 한빛사

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한국과학기술연구원, UST

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Proc. Natl. Acad. Sci. USA, February 28, 2017 vol. 114 no. 9 E1727-E1736 | doi: 10.1073/pnas.1615230114 Differential modulation of global and local neural oscillations in REM sleep by homeostatic sleep regulation

Abstract

Bowon Kim^a,b,1, Bernat Kocsis^c,d,1,2, Eunjin Hwang^a, Youngsoo Kim^c,e, Robert E. Strecker^c,e, Robert W. McCarley^c,e, and Jee Hyun Choi^a,b,2^aCenter for Neuroscience, Korea Institute of Science and Technology, Seoul 02792, South Korea;
^bDepartment of Neuroscience, University of Science and Technology, Daejeon 34113, South Korea;
^cDepartment of Psychiatry, Harvard Medical School, Boston, MA 02215;
^dDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215;
^eResearch Service, Veterans Affairs Boston Healthcare System, Brockton, MA 02301

Abstract
Homeostatic rebound in rapid eye movement (REM) sleep normally occurs after acute sleep deprivation, but REM sleep rebound settles on a persistently elevated level despite continued accumulation of REM sleep debt during chronic sleep restriction (CSR). Using high-density EEG in mice, we studied how this pattern of global regulation is implemented in cortical regions with different functions and network architectures. We found that across all areas, slow oscillations repeated the behavioral pattern of persistent enhancement during CSR, whereas high-frequency oscillations showed progressive increases. This pattern followed a common rule despite marked topographic differences. The findings suggest that REM sleep slow oscillations may translate top-down homeostatic control to widely separated brain regions whereas fast oscillations synchronizing local neuronal ensembles escape this global command. These patterns of EEG oscillation changes are interpreted to reconcile two prevailing theories of the function of sleep, synaptic homeostasis and sleep dependent memory consolidation.

chronic sleep deprivation, low-frequency cortical oscillation, fast cortical oscillation, EEG topography, sleep function
¹B. Kim and B. Kocsis contributed equally to this work.
²To whom correspondence may be addressed.

Author contributions: Y.K., R.E.S., R.W.M., and J.H.C. designed research; B. Kim, E.H., and J.H.C. performed research; B. Kim, B. Kocsis, Y.K., and J.H.C. analyzed data; B. Kocsis contributed new reagents/analytic tools; and B. Kocsis and J.H.C. wrote the paper. The microarrays are available by contacting J.H.C.

논문정보

형식Research article
게재일2017년 02월 (BRIC 등록일 2017-02-21)
연구진국내(교신)+국외 연구진
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