한빛사논문
- 조회1,404
Abstract
Young-Woock Noh1,†, Sun-Young Kim1, Jung-Eun Kim1, Sohyun Kim1, Jooyeon Ryu2, Inhye Kim2, Eunji Lee2, Soong Ho Um1 and Yong Taik Lim1,*
1 SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do, Republic of Korea
2 Graduate School of Analytical Science and Technology, Chungnam National University, Yuseong-gu, Daejeon, Republic of Korea
† Present address: New Drug Development Center, Osong Medical Innovation Foundation, 123 Osongsaengmyeong-ro, Cheongju-si, Chungcheongbuk-do, 363-951, Republic of Korea
Abstract
The design and synthesis of nanoparticles mimicking the key features in size, shape, and surface molecular organization of biological objects that provide danger-signals are essential in the formulation of effective vaccine. Here, multifaceted immunomodulatory nanoliposomes (denoted as “tumosomes”) that can turn tumors into vaccines and induce enhanced antitumor immune response are suggested. Multifaceted tumosomes are synthesized by assembling tumor cell membrane proteins as tumor-associated antigens with two lipid-based adjuvants as pathogen characters (i.e., monophosphoryl lipid A as a danger signal, dimethyldioctadecylammonium as a cell-invasion moiety). The enhanced antitumor immunity of tumosomes afforded by the improved antigenicity and antigen uptake efficiency is also evaluated in a tumor challenge experiment after their image-guided intralymph node injection. Tumosomes are able to provide tumor antigens and molecular adjuvants for the priming of a long-term adaptive immune response in tumor draining lymph nodes, as well as in the spleen. Tumosome injection leads to an inhibition of tumor growth, and the survival rate of mice treated with the tumosomes is higher than those of other groups. Taken together, the tumosomes are expected to be used for the reshaping the immune response in the lymph node and enhanced antitumor immunity.
Keywords : antigen delivery; antitumor immunity; immunomodulation; lymph nodes; nanoliposomes
논문정보
- Research article
- 2017년 01월 (BRIC 등록일 2017-01-20)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
댓글 작성 로그인
팝업 닫기관련 링크
소속기관 논문보기
관련분야 논문보기
