한빛사논문
- 조회1,961
Abstract
Kwangwoo Kim1, So-Young Bang2, Hye-Soon Lee2 and Sang-Cheol Bae2
1 Department of Biology, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
2 Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222?1 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
Correspondence to : Sang-Cheol Bae
Abstract
Human genetic studies into rheumatoid arthritis (RA) have uncovered more than 100 genetic loci associated with susceptibility to RA and have refined the RA-association model for HLA variants. The majority of RA-risk variants are highly shared across multiple ancestral populations and are located in noncoding elements that might have allele-specific regulatory effects in relevant tissues. Emerging multi-omics data, high-density genotype data and bioinformatic approaches are enabling researchers to use RA-risk variants to identify functionally relevant cell types and biological pathways that are involved in impaired immune processes and disease phenotypes. This Review summarizes reported RA-risk loci and the latest insights from human genetic studies into RA pathogenesis, including how genetic data has helped to identify currently available drugs that could be repurposed for patients with RA and the role of genetics in guiding the development of new drugs.
논문정보
- Review Paper
- 2016년 11월 (BRIC 등록일 2016-11-09)
- 국내 연구진
- 의약학 > 응용의학
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
