한빛사논문
- 조회1,042
Abstract
Dong Hyun Sinn1, Danbee Kang2, Yoosoo Chang3,4,5, Seungho Ryu3,4,5, Seonhye Gu6, Hyunkyoung Kim6, Donghyeong Seong2, Soo Jin Cho7, Byoung-Kee Yi2,8, Hyung-Doo Park9, Seung Woon Paik1, Young Bin Song1,10, Mariana Lazo10, Joao A C Lima10, Eliseo Guallar10, Juhee Cho2,3,5,10, Geum-Youn Gwak1,*
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea
2Department of Health Science and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea
3Center for Cohort Studies, Total Healthcare Screening Center, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, South Korea
4Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, South Korea
5Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea
6Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea
7Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea
8Department of Medical Informatics, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea
9Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea
10Departments of Epidemiology and Medicine and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, USA
*Correspondence to Professor Geum-Youn Gwak, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-Gu, Seoul 06351, South Korea; or Professor Juhee Cho, Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-Gu, 06351, Seoul, South Korea; or Professor Juhee Cho, Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-Gu, 06351, Seoul, South Korea
DHS and DK contributed equally.
Abstract
Background and aim Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, was associated with subclinical atherosclerosis in many cross-sectional studies, but the prospective association between NAFLD and the progression of atherosclerosis has not been evaluated. This study was conducted to evaluate the association between NAFLD and the progression of coronary atherosclerosis.
Methods This retrospective cohort study included 4731 adult men and women with no history of cardiovascular disease (CVD), liver disease or cancer at baseline who participated in a repeated regular health screening examination between 2004 and 2013. Fatty liver was diagnosed by ultrasound based on standard criteria, including parenchymal brightness, liver-to-kidney contrast, deep beam attenuation and bright vessel walls. Progression of coronary artery calcium (CAC) scores was measured using multidetector CT scanners.
Results The average duration of follow-up was 3.9 years. During follow-up, the annual rate of CAC progression in participants with and without NAFLD were 22% (95% CI 20% to 23%) and 17% (16% to 18%), respectively (p<0.001). The multivariable ratio of progression rates comparing participants with NAFLD with those without NAFLD was 1.04 (1.02 to 1.05; p<0.001). The association between NAFLD and CAC progression was similar in most subgroups analysed, including in participants with CAC 0 and in those with CAC >0 at baseline.
Conclusions In this large cohort study of adult men and women with no history of CVD, NAFLD was significantly associated with the development of CAC independent of cardiovascular and metabolic risk factors. NAFLD may play a pathophysiological role in atherosclerosis development and may be useful to identify subjects with a higher risk of subclinical disease progression.
논문정보
- Research article
- 2016년 09월 (BRIC 등록일 2016-09-19)
- 국내(교신)+국외 연구진
- 의약학 > 응용의학
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