한빛사논문
- 조회1,655
한국과학기술연구원, State University of New York
Abstract
Ajay Singh1,2, Woong Kim1, Youngsun Kim1, Keunsoo Jeong1, Chi Soo Kang1, YoungSoo Kim1, Joonseok Koh3, Supriya D. Mahajan4, Paras N. Prasad2,* and Sehoon Kim1,*
1 Center for Theragnosis and Center for Neuro-Medicine, Korea Institute of Science and Technology (KIST), Seoul, South Korea
2 Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY, USA
3 Department of Organic and Nano System Engineering, Konkuk University, Seoul, South Korea
4 Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York, Clinical Translational Research Center, Buffalo, NY, USA
*Corresponding author
Abstract
Theranostic photonic nanoparticles (TPNs) that cross the blood-brain barrier (BBB) and efficiently deliver a therapeutic agent to treat brain diseases, simultaneously providing optical tracking of drug delivery and release, are introduced. These TPNs are constructed by physical encapsulation of visible and/or near-infrared photonic molecules, in an ultrasmall micellar structure (<15 nm). Phytochemical curcumin is employed as a therapeutic as well as visible-emitting photonic component. In vitro BBB model studies and animal imaging, as well as ex vivo examination, reveal that these TPNs are capable of transmigration across the BBB and subsequent accumulation near the orthotopic xenograft of glioblastoma multiforme (GBM) that is the most common and aggressive brain tumor whose vasculature retains permeability-resistant properties. The intracranial delivery and release of curcumin can be visualized by imaging fluorescence produced by energy transfer from curcumin as the donor to the near-infrared emitting dye, coloaded in TPN, where curcumin induced apoptosis of glioma cells. At an extremely low dose of TPN, a significant therapeutic outcome against GBM is demonstrated noninvasively by bioluminescence monitoring of time-lapse proliferation of luciferase-expressing U-87 MG human GBM in the brain. This approach of TPN can be generally applied to a broad range of brain diseases.
Keywords : blood-brain barrier; brain tumor therapy; drug delivery; fluorescence imaging; theranostic nanoparticles
논문정보
- Research article
- 2016년 09월 (BRIC 등록일 2016-09-08)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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