한빛사논문
- 조회2,245
Abstract
Myunghoo Kim1, 5, Yaqing Qie1, 5, Jeongho Park1, Chang H. Kim1, 2, 3, 4, *
1 Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA
2 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
3 Purdue Institute for Inflammation, Immunology, and Infectious Diseases, Purdue University, West Lafayette, IN 47907, USA
4 Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA
5Co-first author
*Corresponding author
Summary
Antibody production is a metabolically demanding process that is regulated by gut microbiota, but the microbial products supporting B cell responses remain incompletely identified. We report that short-chain fatty acids (SCFAs), produced by gut microbiota as fermentation products of dietary fiber, support host antibody responses. In B cells, SCFAs increase acetyl-CoA and regulate metabolic sensors to increase oxidative phosphorylation, glycolysis, and fatty acid
synthesis, which produce energy and building blocks supporting antibody production. In parallel, SCFAs control gene expression to express molecules necessary for plasma B cell differentiation. Mice with low SCFA production due to reduced dietary fiber consumption or microbial insufficiency are defective in homeostatic and pathogen-specific antibody responses, resulting in greater pathogen susceptibility. However, SCFA or dietary fiber intake restores this immune deficiency. This B cell-helping function of SCFAs is detected from the intestines to systemic tissues and conserved among mouse and human B cells, highlighting its importance.
논문정보
- Research article
- 2016년 07월 (BRIC 등록일 2016-08-03)
- 국외 연구진
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