최학수 (Massachusetts General Hospital and Harvard Medical School)

한빛사논문

조회1,562

Massachusetts General Hospital and Harvard Medical School

CV File 973 kb

ACS Nano, Publication Date (Web): March 09, 2016 | DOI: 10.1021/acsnano.5b07408 Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging

Abstract

Yanzhao Zhao^†, Minmin Liang^‡, Xiao Li^†, Kelong Fan^‡, Jie Xiao^†, Yanli Li^†, Hongcheng Shi^†, Fei Wang^‡, Hak Soo Choi^*§, Dengfeng Cheng^*†, and Xiyun Yan^*‡

^† Department of Nuclear Medicine, Zhongshan Hospital, Fudan University/Shanghai Institute of Medical Imaging, Shanghai 200032, China
^‡ Key Laboratory of Protein and Peptide Pharmaceutical/Chinese Academy of Sciences-University of Tokyo Joint Laboratory of Structural Virology and Immunology/Beijing Translational Engineering Center of Biomacromolecular Drugs, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
^§ Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, United States

^*Corresponding authors

Abstract
Despite all the advances in multimodal imaging, it remains a significant challenge to acquire both magnetic resonance and nuclear imaging in a single dose because of the enormous difference in sensitivity. Indeed, nuclear imaging is almost 10⁶-fold more sensitive than magnetic resonance imaging (MRI); thus, repeated injections are generally required to obtain sufficient MR signals after nuclear imaging. Here, we show that strategically engineered magnetoferritin nanoprobes can image tumors with high sensitivity and specificity using SPECT and MRI in living mice after a single intravenous injection. The magnetoferritin nanoprobes composed of ¹²⁵I radionuclide-conjugated human H-ferritin iron nanocages (¹²⁵I-M-HFn) internalize robustly into cancer cells via a novel tumor-specific HFn-TfR1 pathway. In particular, the endocytic recycling characteristic of TfR1 transporters solves the nuclear signal blocking issue caused by the high dose nanoprobes injected for MRI, thus enabling simultaneous functional and morphological tumor imaging without reliance on multi-injections.

Keywords: diagnostic imaging; magnetoferritin nanoparticles; multimodal imaging; nuclear signal blocking; tumor targeting

논문정보

형식Research article
게재일2016년 03월 (BRIC 등록일 2016-07-21)
연구진국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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