신의철 (KAIST)

한빛사논문, 상위피인용논문

조회3,625

KAIST

CV File 384 kb

Nat. Rev. Immunol., Published online 04 July 2016 | doi:10.1038/nri.2016.69 Immune responses and immunopathology in acute and chronic viral hepatitis

Abstract

Eui-Cheol Shin^1,*, Pil Soo Sung^1,2 and Su-Hyung Park^3,*

¹Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.
²Division of Hepatology, Department of Internal Medicine, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
³Laboratory of Translational Immunology and Vaccinology, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.

^*Correspondence to : Eui-Cheol Shin or Su-Hyung Park

Abstract
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible for most cases of viral hepatitis. Infection by each type of virus results in a different typical natural disease course and clinical outcome that are determined by virological and immunological factors. HCV tends to establish a chronic persistent infection, whereas HAV does not. HBV is effectively controlled in adults, although it persists for a lifetime after neonatal infection. In this Review, we discuss the similarities and differences in immune responses to and immunopathogenesis of HAV, HBV and HCV infections, which may explain the distinct courses and outcomes of each hepatitis virus infection.

논문정보

형식Review Paper
게재일2016년 07월 (BRIC 등록일 2016-07-08)
연구진국내 연구진
분야 의약학 > 면역의학
피인용횟수60회 이상 인용된 논문 (상위피인용논문 등록일 2019-04-23)

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