김해원 (단국대학교, Columbia University) | 한빛사논문 > 한빛사

한빛사논문

조회1,270

단국대학교, Columbia University

CV File 346 kb

Prog. Mater. Sci., Available online 24 May 2016 | doi:10.1016/j.pmatsci.2016.05.003 Biomaterials control of pluripotent stem cell fate for regenerative therapy

Abstract

Roman A. Perez^{a, b}, Seong-Jun Choi^{a, b}, Cheol-Min Han^{b, c, d}, Jung-Ju Kim^{a, b}, Hosup Shim^{a, b}, Kam W Leong^{a, e}, Hae-Won Kim^{a, b, e,*}

^a Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 330-714, Republic of Korea
^b Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Cheonan, 330-714, Dankook University, Republic of Korea
^c Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, 330-714, Republic of Korea
^d Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
^e Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA

^*Corresponding author

Abstract
Pluripotent stem cells (PSCs) derived from either the embryo or reprogramming processes have the capacity to self-renew and differentiate into various cells in the body, thereby offering a valuable cell source for regenerative therapy of intractable disease and serious tissue damage. Traditionally, methods to expand and differentiate PSCs have been confined to 2D culture through the use of biochemical signals; the use of biomaterials beyond the commercially available culture dish has not been widespread. Nevertheless, biomaterials with tailored physical, chemical, and geometrical cues can mimic the native stem cell niche to tune the microenvironmental conditions for PSCs to preserve their self-renewal capacity or to switch their phenotype, a status ultimately needed to gain regenerative functions ex vivo and in vivo. Recently efforts to explore biomaterials to regulate PSC behavior have accelerated. The biomaterials properties investigated include surface chemistry, immobilized ligand, nano-/micro-topography, matrix stiffness, geometrical complexity, 3D configuration, and combinations thereof. This review aims to cover the current advances of biomaterials-based control over PSCs, particularly for the preservation of self-renewal capacity as well as for their differentiation into target cells. Furthermore, it aims to suggest future research directions that would facilitate the eventual translation of these advances.

Keywords : Pluripotent stem cells; Self-renewal; Lineage differentiation; Biomaterials; Microenvironment

논문정보

형식Review Paper
게재일2016년 05월 (BRIC 등록일 2016-05-30)
연구진국내(교신)+국외 연구진
분야 의약학 > 재생의학

댓글 작성 로그인

CV 열람하기

연락처 보기