한빛사논문
- 조회4,785
Abstract
Gi Seok Jeong1,2, Da Yoon No1,3, JaeSeo Lee4, Junghyo Yoon5, Seok Chung5 & Sang-Hoon Lee1,4
1 Department of Biomedical Engineering, College of Health Science, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, Korea. 2 Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 olympic-Ro, Songpa-gu, Seoul 05505, Korea. 3 Department of Bioengineering, School of Engineering and Medicine, Stanford University, 443 Via Ortega, Stanford, California 94305, USA. 4 KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Korea. 5 School of Mechanical Engineering, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, Korea.
Correspondence to : Sang-Hoon Lee
Abstract
High-aspect ratio micro- and nano-structures have been used for the production of a variety of applications. In this paper, we describe a simple and cost-effective approach to fabricate an arrayed microarchitecture with an ultra-high aspect ratio using soft materials. The shapes and sizes of the honeycomb structure can be easily modulated by changing the dimensions and position of the base mould pattern and the pressure. The honeycomb structure is used to prepare a drug delivery patch and a microwell array to form cell spheroids without cell loss. The honeycomb structures prepared using natural ECM (collagen?Matrigel) materials are successfully fabricated. The hepatocytes and endothelial cells are seeded and co-cultured in the ECM-based micro-honeycomb to prepare a 3D liver model successfully mimicking an ultrastructure of liver and providing enhanced liver function.
논문정보
- Research article
- 2016년 05월 (BRIC 등록일 2016-05-17)
- 국내(교신)+국외 연구진
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