한빛사논문
- 조회1,248
Abstract
Hye In Park1, 2, Hyun Woung Yoon1, 2, Sang Taek Jung1,*
1 Department of Bio and Nano Chemistry, Kookmin University, Seoul 136-702, Korea
2 These authors contributed equally to this work.
*Correspondence : Sang Taek Jung
The Fc region of the IgG antibody recruits immune leukocytes or serum complement molecules, which in turn triggers the clearance of defective cells such as tumor cells or infected cells. In addition, the Fc region is crucial for the prolonged serum persistence of circulating IgG antibodies through an intracellular trafficking and recycling mechanism. Recently, the utility of antibody Fc has been further expanded to include a new class of antigen-binding scaffolds. This review presents the recent progress in the field of antibody Fc engineering and highlights new biomolecular, cellular, and evolutionary approaches to overcome the limitations of conventional monoclonal therapeutic antibodies by engineering the antibody Fc domain.
논문정보
- Review Paper
- 2016년 05월 (BRIC 등록일 2016-05-13)
- 국내 연구진
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