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Cell, Volume 164, Issues 1-2, 14 January 2016, Pages 208–218, doi:10.1016/j.cell.2015.11.038
Prefrontal Parvalbumin Neurons in Control of Attention
Abstract
Hoseok Kim1, Sofie Ährlund-Richter1, Xinming Wang1, Karl Deisseroth2, 3, 4, Marie Carlén1,*
1 Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden
2 Howard Hughes Medical Institute, W080 Clark Center, 318 Campus Drive West, Stanford University, Stanford, CA 94305, USA
3 Department of Bioengineering, W080 Clark Center, 318 Campus Drive West, Stanford University, Stanford, CA 94305, USA
4 Department of Psychiatry and Behavioral Sciences, W080 Clark Center, 318 Campus Drive West, Stanford University, Stanford, CA 94305, USA
*Correspondence
Summary
While signatures of attention have been extensively studied in sensory systems, the neural sources and computations responsible for top-down control of attention are largely unknown. Using chronic recordings in mice, we found that fast-spiking parvalbumin (FS-PV) interneurons in medial prefrontal cortex (mPFC) uniformly show increased and sustained firing during goal-driven attentional processing, correlating to the level of attention. Elevated activity of FS-PV neurons on the timescale of seconds predicted successful execution of behavior. Successful allocation of attention was characterized by strong synchronization of FS-PV neurons, increased gamma oscillations, and phase locking of pyramidal firing. Phase-locked pyramidal neurons showed gamma-phase-dependent rate modulation during successful attentional processing. Optogenetic silencing of FS-PV neurons deteriorated attentional processing, while optogenetic synchronization of FS-PV neurons at gamma frequencies had pro-cognitive effects and improved goal-directed behavior. FS-PV neurons thus act as a functional unit coordinating the activity in the local mPFC circuit during goal-driven attentional processing.
논문정보
- Research article
- 2016년 01월 (BRIC 등록일 2016-01-25)
- 국외 연구진
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