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Purdue University

NPG Asia Mater., Published online 27 November 2015, 7, e227 | doi:10.1038/am.2015.114 Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants

Abstract

Chi Hwan Lee^1,2,11, Hojun Kim^3,11, Daniel V Harburg^2,11, Gayoung Park^4,5, Yinji Ma^6,7, Taisong Pan^6,8, Jae Soon Kim⁹, Na Yeon Lee¹⁰, Bong Hoon Kim², Kyung-In Jang², Seung-Kyun Kang², Yonggang Huang⁶, Jeongmin Kim⁵, Kyung-Mi Lee⁵, Cecilia Leal² and John A Rogers²

¹Weldon School of Biomedical Engineering and School of Mechanical Engineering and The Center for Implantable Devices and Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA

²Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA

³Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA

⁴Department of Biomicrosystem Technology, Korea University, Seoul, Republic of Korea

⁵Department of Biochemistry and Molecular Biology, Global Research Laboratory, Korea University College of Medicine, Seoul, Republic of Korea

⁶Department of Civil and Environmental Engineering, and Mechanical Engineering, Center for Engineering and Health and Skin Disease Resesarch Center, Northwestern University, Evanston, IL, USA

⁷Center for Mechanics and Materials, Tsinghua University, Beijing, China

⁸State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Sichuan, China

⁹Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA

¹⁰Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA

¹¹These authors contributed equally to this work.

Correspondence: Professor C Leal or Professor JA Rogers, Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, 308 Materials Science and Engineering Building, 1304 W. Green Street, Urbana, IL 61801, USA.

Abstract

On-demand, localized release of drugs in precisely controlled, patient-specific time sequences represents an ideal scenario for pharmacological treatment of various forms of hormone imbalances, malignant cancers, osteoporosis, diabetic conditions and others. We present a wirelessly operated, implantable drug delivery system that offers such capabilities in a form that undergoes complete bioresorption after an engineered functional period, thereby obviating the need for surgical extraction. The device architecture combines thermally actuated lipid membranes embedded with multiple types of drugs, configured in spatial arrays and co-located with individually addressable, wireless elements for Joule heating. The result provides the ability for externally triggered, precision dosage of drugs with high levels of control and negligible unwanted leakage, all without the need for surgical removal. In vitro and in vivo investigations reveal all of the underlying operational and materials aspects, as well as the basic efficacy and biocompatibility of these systems.

논문정보

형식Research article
게재일2015년 11월 (BRIC 등록일 2015-12-08)
연구진국내+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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