한빛사
>
한빛사논문
한빛사논문
- 조회1,740
J. Am. Chem. Soc., Publication Date (Web): September 23, 2015 | DOI: 10.1021/jacs.5b08678
Enhancing DNA-Mediated Assemblies of Supramolecular Cage Dimers through Tuning Core Flexibility and DNA Length—A Combined Experimental–Modeling Study
Abstract
Bong Jin Hong†§, Vincent Y. Cho†§, Reiner Bleher‡, George C. Schatz*†, and SonBinh T. Nguyen*†
† Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States
‡ NUANCE Center and Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208-3108, United States
§Author Contributions
B.J.H. and V.Y.C. contributed equally.
*Corresponding authors
Abstract
B.J.H. and V.Y.C. contributed equally.
*Corresponding authors
Abstract
Two complementary small-molecule-DNA hybrid (SMDH) building blocks have been combined to form well-defined supramolecular cage dimers at DNA concentrations as high as 102 μM. This was made possible by combining a flexible small-molecule core and three DNA arms of moderate lengths (＜20 base pairs). These results were successfully modeled by coarse-grained molecular dynamics simulations, which also revealed that the formation of ill-defined networks in the case of longer DNA arms can be significantly biased by the presence of deep kinetic traps. Notably, melting point studies revealed that cooperative melting behavior can be used as a means to distinguish the relative propensities for dimer versus network formation from complementary flexible three-DNA-arm SMDH (fSMDH3) components: sharp, enhanced melting transitions were observed for assemblies that result mostly in cage dimers, while no cooperative melting behavior was observed for assemblies that form ill-defined networks.
논문정보
- Research article
- 2015년 09월 (BRIC 등록일 2015-10-16)
- 국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
