한빛사
>
한빛사논문
한빛사논문
- 조회2,439
Sci. Transl. Med., 29 Jul 2015: Vol. 7, Issue 298, pp. 298ra118 | DOI: 10.1126/scitranslmed.aac5546
Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity
Ja-Won Koo1,2,*, Lourdes Quintanilla-Dieck1,*, Meiyan Jiang1,*, Jianping Liu1,3,*, Zachary D. Urdang1,*, Jordan J. Allensworth1,*, Campbell P. Cross1,*, Hongzhe Li1,* and Peter S. Steyger1,*,†
1Oregon Hearing Research Center, Department of Otolaryngology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.
2Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 173-82 Kumiro, Bundang-gu, Seongnam 463-707, Republic of Korea.
3Department of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China.
† Corresponding author : Peter S. Steyger
* All authors contributed equally to this work.
Abstract
Aminoglycoside antibiotics are essential for treating life-threatening infections, despite the known risk of permanent hearing loss by damaging cochlear sensory cells in the inner ear. Because severe infections also trigger widespread inflammation, Koo and colleagues tested the effect of inflammation on aminoglycoside-induced hearing loss as a model of clinical dosing with these drugs. Systemic inflammation increased cochlear uptake of aminoglycosides and, surprisingly, cochlear expression of inflammatory markers in mice. Inflammation also greatly exacerbated aminoglycoside-induced hearing loss and cochlear sensory cell death in sick mice compared to healthy mice. These findings may help clinicians to choose the appropriate pharmacotherapy for patients with severe infections to better protect lifelong hearing health, and encourage the development of otoprotective drugs that also demonstrate efficacy against aminoglycoside-induced ototoxicity during infection-induced inflammation.
논문정보
- Research article
- 2015년 07월 (BRIC 등록일 2015-08-11)
- 국내+국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
