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한빛사논문
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Nat. Methods, Published online 22 June 2015 | doi:10.1038/nmeth.3449
Single-cell magnetic imaging using a quantum diamond microscope
Abstract
David R Glenn1,8, Kyungheon Lee2,8, Hongkun Park3.5, Ralph Weissleder2,6, Amir Yacoby3, Mikhail D Lukin3, Hakho Lee2,*, Ronald L Walsworth1,3,5,* & Colin B Connolly7,*
1Harvard-Smithsonian Center for Astrophysics, Cambridge, Massachusetts, USA. 2Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. 3Department of Physics, Harvard University, Cambridge, Massachusetts, USA. 4Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA. 5Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA. 6Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA. 7Quantum Diamond Technologies, Inc., Somerville, Massachusetts, USA. 8These authors contributed equally to this work.
*Correspondence to : Hakho Lee or Ronald L Walsworth or Colin B Connolly
We apply a quantum diamond microscope for detection and imaging of immunomagnetically labeled cells. This instrument uses nitrogen-vacancy (NV) centers in diamond for correlated magnetic and fluorescence imaging. Our device provides single-cell resolution and a field of view (~1 mm2) two orders of magnitude larger than that of previous NV imaging technologies, enabling practical applications. To illustrate, we quantified cancer biomarkers expressed by rare tumor cells in a large population of healthy cells.
논문정보
- Research article
- 2015년 06월 (BRIC 등록일 2015-06-26)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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