한빛사논문
- 조회2,798
Abstract
Junsung Lee1,4,6,7, Jiyoung Kim2,4,7, Moonkyoung Jeong2,4, Hyoungjin Lee2,4, Unbyeol Goh2,4, Hyaeyeong Kim3,4, Byungji Kim2,4, and Ji-Ho Park1,2,4,5,*
1Graduate School of Medical Science and Engineering, 2Department of Bio and Brain Engineering, 3Department of Chemistry, 4Institute for Optical Science and Technology, and 5Institute for the Nanocentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-338, Republic of Korea.
6Present address: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 501-757, Republic of Korea.
7These authors contributed equally to this work.
*Corresponding author : Ji-Ho Park
Abstract
Natural membrane vesicles (MVs) derived from various types of cells play an essential role in transporting biological materials between cells. Here, we show that exogenous compounds are packaged in the MVs by engineering the parental cells via liposomes, and the MVs mediate autonomous intercellular migration of the compounds through multiple cancer cell layers. Hydrophobic compounds delivered selectively to the plasma membrane of cancer cells using synthetic membrane fusogenic liposomes were efficiently incorporated into the membrane of MVs secreted from the cells, and then transferred to neighboring cells via the MVs. This liposome-mediated MV engineering strategy allowed hydrophobic photosensitizer to significantly penetrate both spheroids and in vivo tumors, thereby enhancing the therapeutic efficacy. These results suggest that innate biological transport systems can be in situ engineered via synthetic liposomes to guide the penetration of chemotherapeutics across challenging tissue barriers in solid tumors.
KEYWORDS: liposome, membrane vesicle, nanomedicine, photosensitizer, spheroid
논문정보
- Research article
- 2015년 03월 (BRIC 등록일 2015-04-03)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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