한빛사논문
- 조회4,316
Abstract
Jaewon Ko1, 2, Gayoung Choii1, Ji Won Um1, 3
1 Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea
2 Department of Psychiatry, Yonsei University College of Medicine, Seoul 120-751, Korea
3 Department of Physiology, Yonsei University College of Medicine, Seoul 120-751, Korea
Corresponding authors: Jaewon Ko, Ji Won Um
Summary
GABA (γ-aminobutyric acid) is the main neurotransmitter at inhibitory synapses in the mammalian brain. It is essential for maintaining the excitation and inhibition (E/I) ratio, whose imbalance underlies various brain diseases. Emerging information about inhibitory synapse organizers provides a novel molecular framework for understanding E/I balance at the synapse, circuit, and systems levels. This review highlights recent advances in deciphering these components of the inhibitory synapse and their roles in the development, transmission, and circuit properties of inhibitory synapses. We also discuss how their dysfunction may lead to a variety of brain disorders, suggesting new therapeutic strategies based on balancing the E/I ratio.
Keywords : inhibitory synapse; GABA; synaptic adhesion; excitation-inhibition balance; synapse organizer
논문정보
- Review Paper
- 2015년 04월 (BRIC 등록일 2015-04-01)
- 국내 연구진
- 생명과학 > 신경생물학
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